CHO Quasispecies—Implications for Manufacturing Processes

CHO Quasispecies—Implications for Manufacturing Processes

Chinese hamster ovary (CHO) cells are a source of multi-ton quantities of protein pharmaceuticals. They are, however, immortalized cells, characterized by a high degree of genetic and phenotypic diversity. As is known for any biological system, this diversity is enhanced by selective forces when laboratories (no sharing of gene pools) grow cells under (diverse) conditions that are practical and...

Manufacturing Processes

Electromagnetic forming (EM forming or magneforming) is a type of high velocity, cold forming process for electrically conductive metals, most commonly copper and aluminum. The work piece is reshaped by high intensity pulsed magnetic fields that induce a current in the work piece and a corresponding repulsive magnetic field, rapidly repelling portions of the work piece. The work piece can be re...

Kalman Filtering for Manufacturing Processes

Reliability estimation for manufacturing processes

Purpose: of the current research is to develop a reliability assessment method with an extension of the existing ones and pooling them to a common framework. The system must identify the most unreliable parts of a production process and suggest the most efficient ways for the reliability improvement. Design/methodology/approach: FMEA is in the centre of the proposed framework,a reliability anal...

Improved Methods for Production Manufacturing Processes in Environmentally Benign Manufacturing

How to design a production process with low carbon emissions and low environmental impact as well as high manufacturing performance is a key factor in the success of low-carbon production. It is important to address concerns about climate change for the large carbon emission source manufacturing industries because of their high energy consumption and environmental impact during the manufacturin...